Dr. Felicia Keesing Professor of Biology at Bard College, Cary Adjunct Scientist Share: May 18, 2020 COVID-19 In my last post, Herd immunity, I began with a thought experiment: what would happen if everyone in the world sat down, at least six feet apart, for 14 days? If we could do it, the pandemic would be over, because anyone who was infected would recover (or die from) their infection without passing it on to anyone else. In epidemiological terms, we would have reduced Rt, the effective reproduction number  of the virus, to zero, or Rt = 0.But in reality, we’re not talking about reducing Rt to zero at the moment because we can’t . In fact, what we’re talking about is trying to reduce Rt to a number less than 1, like 0.9 or 0.8. What does that mean? If Rt is 1, it means that one infected person transmits the infection to one other person, on average. Over time, with Rt = 1, the number of infected people would stay the same, but the actual people who were infected would change. Another way to say this is that if 10 people were infected, they’d infect a total of 10 others.What does it mean to say that Rt is less than one?It means that if 10 people were infected, they’d infect only 9 others (in the case of Rt = 0.9) or 8 others (in the case of Rt = 0.8). Whenever Rt is less than one, there will be fewer and fewer infected people over time. The further Rt is below one, the faster this decline will happen.Right now in the United States, most states have an estimated Rt of between 0.75 and 0.98. A handful of states have Rt above 1, but even the highest – Minnesota this week – is only at 1.05. This means that what we’re doing is working. We’re reducing transmission through hygiene, social distancing, and self-quarantining, and it’s causing the number of cases to go down over time.In higher education right now, there’s much debate about whether colleges and universities can safely reopen for in-person instruction in the fall. Photo: Biobess via Flickr.In most places, if we kept doing what we’ve been doing for long enough, the disease would slowly, slowly decline, potentially to zeroThe three important points about this are these:The decline to zero would take a long time. Months and months. And months.Along the way, more and more people would be getting infected, and some of them would die. The total number of people infected at any one moment would be declining, but the actual people suffering would keep changing.As soon as we change what we’re doing about social distancing, hygiene, and quarantining, Rt will change as well, almost certainly by going up.Unfortunately, though, many of our decision-makers, and perhaps many of us as well, think that if the number of cases is going down, we can start to go back to normalAnd many are using the Rt measures as a justification, either explicitly or implicitly. We need to remember that if we start to go back to normal, the number of cases will start to rise again, and Rt will go back up. At best, this could mean modest increases that we can manage, as Germany is currently trying to do. At worst, we could end up right back where we were in March.But there’s yet another critical misunderstanding and it’s having a huge effect on the decisions that people are discussing about when to restart businesses and institutions, and how.In higher education right now, for example, there’s much debate about whether colleges and universities can safely reopen for in-person instruction in the fall. The assumption behind many of these plans is that if we could find a way to create a low-density campus, we could re-open safely. Campuses are famously high-density places, which is part of why they are such dynamic spaces for learning and living and doing. So how does one create a low-density campus? There are at least 15 solutions being widely considered, including bringing only first-year students back for in-person classes, or offering some classes in person and others virtually.To understand whether these scenarios would be safe – and which ones – we need to explore the concept of thresholds.In science, we think a lot about thresholds – levels above or below which something important changes in a fundamental way. Rt itself is often thought of as a threshold. If Rt is above 1, the disease is spreading. If Rt is below one, the disease is dwindling. So Rt=1 is an important threshold with different outcomes just above and just below it. We use thresholds in our daily lives a lot. The speed limit is a good example. If you’re driving above the speed limit, you’re breaking the law. Below it, you’re not. So when you’re above a threshold, you’re in one category, and when you’re below it, you’re in another.We could reopen higher-density settings (fairly) safely if we could test everyone daily, trace their contacts, and quarantine anyone who tests positive. But we can’t. Photo: National Guard.A problem for many of the reopening scenarios is that they assume that there is a threshold density below which students (or workers) returning to campuses (or offices) will be “safe” and above which they won’t be. But at least for now, there isn’t. For now, the less contact infected people have with others, the safer it will be. It’s not a threshold. It’s a continuum.In New York, Governor Cuomo understands this. That’s why the state’s plans for the first phase of reopening focus on businesses and activities that will let people move around more, but come into minimal contact. That’s a yes for curbside delivery and tennis, and a no for eat-in dining and team sports. These limits acknowledge that there is currently no threshold density that’s safe.If we want to reach the thresholds of safe or normal, we will need better solutionsFor example, we could reopen higher-density settings, including campuses, (fairly) safely if we could test everyone daily, trace their contacts, and quarantine anyone who tests positive. But we can’t . We could reach a threshold of something like normal if we had a safe, effective, and widely available vaccine. But we don’t.As we plan the details of when and how to reopen more spaces and activities going forward, we face two critical issues.How to lower the risks as much as possibleThis involves finding ways to maximize both hygiene (think masks, hand sanitizer, and extra cleanings) and distancing (think single-occupancy spaces, and socially-distant cafeterias). We must also have a workable plan for what to do when people inevitably become sick. How do we detect infected people quickly, and how do we responsibly and efficiently identify their contacts? For colleges and universities, how do we quarantine sick students? And how do we protect the most vulnerable?Determining what level of risk is acceptableWith the tools we currently have, it’s not a question of whether creating lower-density campuses or businesses is safe. It’s a question of whether it’s safe enough. That’s not a scientific question, and it doesn’t have a scientific answer.NotesThe effective reproduction number Rt is different from Ro (R-nought), though they’re related. Ro is the number of cases that would arise if an infected person was in a population in which everyone else was susceptible to infection. In theory at least, it’s an immutable property of a pathogen. In contrast, when some people are immune, through prior exposure or vaccination, or when people take active steps to reduce transmission (like washing hands or social-distancing or wearing masks), we need a different number. That’s Rt. It’s a measure of the number of new cases that are actually arising from each infected person, and it can change based on our behavior.Except in New Zealand, where the badass government and public health experts have pulled this off.If you’re thinking about herd immunity, which I wrote about in my last post, herd immunity is indeed based on a threshold. Above a certain level of immunity in the population, cases will decline. Below that level of immunity, they’ll continue to increase. So it’s a threshold in the same sense that Rt=1 is. But above the threshold of herd immunity, people will still get sick and die – unless virtually everyone is immune through prior exposure or vaccination.Quick tests are available now, but they’re not available enough. Share: Dr. Felicia Keesing Professor of Biology at Bard College, Cary Adjunct Scientist Felicia Keesing has been studying the ecology of infectious diseases since 1998 and is the author of over 70 scientific papers. She is a professor of biology at Bard College and co-leads The Tick Project with Rick Ostfeld, a study testing whether neighborhood-based prevention can reduce human exposure to Lyme and other tick-borne diseases.